ORGANOID RESPONSE BENCHMARK INTELLIGENCE FOR ORBIT

Know how human tissue responds to spaceflight, before it leaves the ground.

A virtual organoid model that predicts cell-death response from bulk RNA-seq, so mission teams can benchmark biology in silico before a sample flies.

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Illustration: an organoid of coral and cobalt glass cells, ringed by an orbit and a satellite, above Earth at night
ORB/TWIN-01 · LEO ALT [— KM] · μg
INPUT · BULK RNA-SEQ MODEL · 3D ORGANOID OUTPUT · CELL-DEATH SCORE
FROM HUMAN CELLS TO ORBIT AND BACK
01Human cellsPatient-derived and stem-cell lines as the starting biology.
02Organoids3D tissue models that keep the architecture a flat dish loses.
03OrbitMicrogravity and radiation, as crews experience them.
04Bulk RNA-seqThe transcriptome data missions actually bring home.
05PredictionA benchmarked cell-death score for each tissue and condition.
PLATFORM

A virtual organoid, trained for orbit.

Three layers that turn returned sequencing data into a decision a mission team can act on.

Illustration: close-up of a coral glass organoid with cobalt nuclei around an open lumen
LAYER 01 · TWIN

Virtual organoid twin

Simulate how a [TISSUE] organoid responds to spaceflight conditions before the sample is loaded on a payload.

LAYER 02 · DATA

Bulk RNA-seq native

Built on the transcriptomes missions return. No spatial assay required to get a tissue-level answer.

LAYER 03 · BENCHMARK

Cell-death benchmark

One comparable score for regulated cell death across tissues, missions and ground controls.

FROM CELL TO ORBIT
MULTIOMICS

The transcriptome first. Every layer next.

ORBIO starts from bulk RNA-seq, the data spaceflight studies already return, and is built to take on further omics layers as they become available.

TRANSCRIPTOME · LIVE PROTEOME · [ROADMAP] METABOLOME · [ROADMAP] GENOME · [ROADMAP]
Illustration: a glowing organoid encircled by coral and cobalt nucleic-acid helices and molecular chains
Illustration: an astronaut's visor reflecting a glowing organoid, its orbit and the curve of Earth
SCIENCE

Built for the crew, measured in tissue.

Every astronaut carries the same human biology we model on the ground. ORBIO reads the transcriptome of organoids exposed to spaceflight conditions and benchmarks how close each tissue comes to regulated cell death.

[N]Tissue types
[N]Flight datasets
[METRIC]Benchmark score
Illustration: a human hand and a chrome robotic hand reaching toward a glowing organoid between them
HUMAN BIOLOGY · MACHINE FORESIGHT
EARLY PARTNERS

Flying organoids? Benchmark them first.

We're working with early partners across space agencies, payload developers and biopharma. Tell us about your mission.

contact@spaceorbio.com